Antitumoral activity of lenalidomide in in vitro and in vivo models of mantle cell lymphoma involves the destabilization of cyclin D1/p27 complexes
نویسندگان
چکیده
Financial support: Fondo de Investigación Sanitaria (PI09/0060 and PI12/01847) (to GR), Ligue contre le Cancer – Comité du Calvados (to BS), Ministerio de Ciencia e Innovación (SAF 09/9503 and SAF 12/31242) (to DC), Redes Temáticas de Investigación Cooperativa de Cáncer from the Instituto de Salud Carlos III (ISCIII) (RD2006/20/014 and RD12/0036/0004) and Generalitat de Catalunya 2009SGR967 (to DC), European Regional Development Fund (ERDF) “Una manera de hacer Europa”. AM was recipient of a predoctoral fellowship from IDIBAPS. AM is supported by Instituto de Salud Carlos III, Fondo de Investigación Sanitaria and FEDER PI11/00907. SB and JC were supported by the Ministère de l’Enseignement Supérieur et de la Recherche (MESR) and by the Conseil Régional de Basse-Normandie (CRBN), respectively.
منابع مشابه
Antitumoral activity of lenalidomide in in vitro and in vivo models of mantle cell lymphoma involves the destabilization of cyclin D1/p27KIP1 complexes.
PURPOSE Clinical responses to the immmunomodulatory drug lenalidomide have been observed in patients with relapsed/refractory mantle cell lymphoma (MCL), although its mechanism of action remains partially unknown. We investigated whether the expression and subcellular localization of cyclin D1, a major cell-cycle regulator overexpressed in MCL, and the cyclin-dependent kinase inhibitor p27(KIP1...
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p27 is a cyclin-dependent kinase inhibitor that plays a critical role in regulating G(1)/S progression, and whose activity is, in part, regulated through interactions with D-type cyclins. Mantle cell lymphoma (MCL) is characterized by the t(11;14) translocation resulting in deregulated cyclin D1. We previously showed that p27 expression in MCL, as assessed by immunohistochemistry (IHC), does no...
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Background: Lenalidomide, a synthetic immunomodulatory drug, has a wide range of features including anti-angiogenic and anti-proliferative properties. To date, researchers have shown that lenalidomide is capable of ameliorating the immune system factors and antitumor responses. Most researchers have reported that lenalidomide enhances the immune response in certain cancer patients through sever...
متن کاملSequestration of p27protein by cyclin D1 in typical and blastic variants of mantle cell lymphomas (MCL): Implications for pathogenesis
P27 is a cyclin dependent kinase inhibitor that plays a critical role in regulating G1/S progression, and whose activity is, in part, regulated through interactions with D type cyclins. Mantle cell lymphoma (MCL) is characterized by the t(11;14) translocation resulting in deregulated cyclin D1. We previously showed that p27 expression, as assessed by immunohistochemistry (IHC) in MCL, does not ...
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Purpose: A deregulated epigenome contributes to the transformed phenotype of mantle cell lymphoma (MCL). This involves activity of the polycomb repressive complex (PRC) 2, containing three core proteins, EZH2, SUZ12, and EED, in which the SET domain of EZH2 mediates the histone methyltransferase activity. We determined the effects of 3-deazaneplanocin A (DZNep), an S-adenosylhomocysteine hydrol...
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